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Changes of immune pattern in lung cancer patients before and after chemotherapy
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Abstract:
Objective: To investigate the changes of lymphocytes number, proportions of lymphocyte subsets, phenotypes and the cytotoxic function of lymphocytes in lung cancer patients before and after chemotherapy and to assess its clinical relevance. Methods: White blood cells (WBC), lymphocytes and neutrophils were counted before and after chemotherapy in 23 patients with lung cancer. Flow cytometery technique was used to determine and analyze the proportions and phenotypes of CD3+, CD4+ and CD8+ lymphocyte subsets. Memory-like phenotype and cytotoxic function of lymphocytes against K562 cells were detected after peripheral lymphocytes were simulated with PHA for 48 h. Results: Lymphopenia setting (decreased and ensuing recovered cell numbers of WBC, neutrophils and lymphocytes) was observed after chemotherapy. The proportion of CD3+ T cells and the ratio of CD8+/CD4+ were slightly increased and the memory-like phenotype, CD44high and CD62Llow, were exhibited after chemotherapy. The cytotoxicity of lymphocytes against K562 target cells was not decreased, but increased in some patients. Conclusion: Chemotherapy does not hamper, but improve the immune environment in lung cancer patients, which provides a reference for clinical immunotherapy after chemotherapy.
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