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Relationship between serum levels of vascular endothelial growth factor and endostatin with clinico-pathological characteristics of patients with gastrointestinal cancer
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Abstract:
Objective: To study the relationship between serum levels of vascular endothelial growthfactor (VEGF), endostatin and pathological characteristics of patients with gastrointestinal cancer. Methods:Serum VEGF and endostatin levels were measured by enzyme-linked immunoassay in 60 patients with gastric carcinoma, 55 with hepatocellular carcinoma, 58 with colorectal carcinoma before and after surgical resection (two weeks later) and in control groups, which included 30 patients with chronic gastritis, 30 with chronic hepatitis B, 30 with adenoma of colon and 30 healthy persons. Results: The preoperative levels of VEGF and endostatin in patients with gastric carcinoma, hepatocellular carcinoma and colorectal carcinoma were significantly higher than those in patients with chronic gastritis, chronic hepatitis B, adenoma of colon and healthy persons (P<0.01). The pre-operation VEGF and endostatin levels were closely related to the grades of cell differentiation, size of the primary tumors, depth of invasion, regional lymph-node metastasis, distant metastasis and pathological stage (P<0.01), but not to tumor site and sex (P>0.05). The post-operation VEGF levels were significantly lower than that of pre-operation (P<0.01), while postoperative endostatin levels were significantly higher than that of preoperation(P<0.01). Conclusion: Elevated serum VEGF and endostatin levels in patients with gastirc, hepatocellular and colorectal carcinoma are closely correlated to the grade of cell differentiation, size of the primary tumors, invasion, metastases and pathological stages. Serum VEGF and endostatin levels may be used for evaluating the biological behavior, invasion and metastasis of gastric, hepatocellular and colorectal carcinoma preoperatively.
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