Mobile website
Expression of Cyclin G mRNA in leukemia patients and its clinical significance
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective: To investigate the expression of Cyclin G mRNA in leukemia patients and its clinical significance. Methods: RT-PCR was used to analyze the expression of Cyclin G mRNA in the mononuclear cells of 129 leukemia patients and 10 healthy controls. Results: (1) The expression of Cyclin G in acute leukemia (AL) and chronic leukemia (CL) patients was significantly higher than that in healthy controls (both P<0.05), but there was no significant difference between AL and CL patients. (2) The Cyclin G positive rates of newly diagnosed/recurrent cases in AL, acute myeloid leukaemia (AML), acute lymphoblastic leukemia (ALL) groups were respectively 71.3%, 66.7%, and 85.7%, all significantly higher than those of their corresponding remission cases（P<0.05 or P<0.01）and that of healthy controls (P<0.01). (3) The Cyclin G positive rates in newly diagnosed cases of different ages, sexes, and percent of immature cells were similar; the positive rates of newly diagnosed cases with WBC > 50×109/L in AL and AML groups were significantly higher than those with WBC ≤ 50×109/L. (4) Fifty-three of the newly diagnosed cases were Cyclin G positive. The remission rate of patients with high Cyclin G expression（51.7%）was significantly lower than that with low Cyclin G expression（79.1%）(P<0.05). Conclusion: The high expression of Cyclin G may be correlated with the pathogenesis of leukemia and may be one of the factors for the poor prognosis of leukemia.
Keywords:
Project Supported:
Clc Number:
