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Clinical Research
iASPP and ASPP2 expressions in non-small cell lung cancer tisseues and their relationship with clinical characteristics
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Abstract:
Abstract Objective:To investigate expressions of iASPP and ASPP2 proteins in primary non-small cell lung cancer (NSCLC), and their relationship with P53 expression and the clinical characteristics of NSCLC. Methods: Specimens of 54 non-small cell lung cancer (NSCLC) patients, who were treated by surgery from Jan. to Dec. 2005 in Hospital of Guiyang Medical College, were included in this study. The expressions of iASPP, ASPP2 and P53 proteins were detected by immunohistochemistry staining and Western blotting analysis. iASPP and ASPP2 differential expressions in NSCLC tissues and adjacent cancer tissues and their relationship with P53 expression and clinical characteristics of NSCLC were analyzed. Results: The positive expression rate of iASPP in P53-negative NSCLC tissues was 71%, which was significantly higher than that in the 4 adjacent cancer tissues (21%, P=0.001). ASPP2 protein expression in NSCLC tissues was not significantly different from that in the adjacent lung tissues. iASPP expression in NSCLC tissues was significantly higher than that in the adjacent cancer tissues ( [0.57±0.36] vs [0.28±0.24], P=0.001). ASPP2 expression in NSCLC tissues was not significantly different from that in the adjacent lung tissues. iASPP and ASPP2 protein expressions in P53 positive NSCLC tissues were similar to those in the adjacent cancer tissues (P>0.05). iASPP protein expression in P53-negative NSCLC tissues was significantly higher than that in P53-positive NSCLC tissues (P<0.05). ASPP2 protein expression in P53-negative NSCLC tissues had no significant difference with that in P53-positive NSCLC tissues (P<0.05). iASPP and ASPP2 protein expressions in NSCLC patients were similar in patients of different genders, ages, pathology types, pathology grades, and clincial stages. Conclusion: iASPP expression is correlated with P53 expression in NSCLC tissues, with iASPP highly expressed in P53-negative NSCLC tissues. Expressions of iASPP and ASPP2 proteins have no correlation with the clinical characteristics of NSCLC.
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Project Supported:
Project supported by the Key International Cooperative Foundation of Guizhou Province (No.200411011), and the Special Foundation for Outstanding Specialist of Science and Technology and Education of Guizhou Province (No.200579)
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