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RhoGDI protein expression in lung cancer tissues and its relationship with clinicopathological characteristics
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Abstract:
Abstract Objective: To investigate the expression of Rho guanine nucleotide dissociation inhibitor(RhoGDI) protein in lung cancer and to evaluate its clinical significance. Methods: The expression of RhoGDI protein in 39 lung cancer specimens and 5 lung inflammatory pseudotumor tissues were detected by Western blotting analysis. The tissues were collected from patients treated in the two affiliated hospitals of Soochow University during 2007-2008. The relationship between RhoGDI expression and the clinical and pathological characteristics of lung cancer were analyzed. Results: RhoGDI protein level in small-cell lung cancer(SCLC) tissues was significantly higher than those in non-small cell lung cancer (NSCLC) and inflammatory pseudotumor tissues ([0.903±0.228] vs [0.522±0.152], [0.485±0.095], P<0.05). RhoGDI protein level was significantly higher in poorly-differentiated tumors than those in moderately-, highly-differentiated NSCLC and inflammatory pseudotumor tissues ([0.649±0.123] vs [0.458±0.138], [0.485±0.095], P<0.05). RhoGDI protein level in squamous carcinoma had no difference with that in adenocarcinoma. The level of RhoGDI protein in NSCLC tissues was increased gradually when the pathology of tumor stage increased (Ⅰ-Ⅲ), but with no significant difference was found among them (F=0.6, P>0.05). RhoGDI protein level in lung cancer was not related to the tumor size (t=1.15, P>0.05) or lymphatic metastasis (t=1.648, P>0.05). RhoGDI protein expression in NSCLC was positively correlated with the serum levels of lactate dehydrogenate (r=0.46, P＜0.01). Conclusion: RhoGDI protein expression is correlated with pathological characteristics and differentiation stages of lung cancer.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No.30570548)
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