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Oncogene addiction: a new approach for tumor-targeted drugs
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Abstract:
Abstract Tumor is a chronic disease caused by accumulation of gene mutation, but the development and progression of certain tumors is dependent on one or a few genes, which is called oncogene addiction or oncogene dependent phenomenon. Weinstein first described this phenomenon as ‘oncogene addiction’ early in 2002, and to date there have been 3 models to explain this phenomenon, namely, the ‘bizarre circuitry model’, ‘oncogenic shock model’, and ‘oncogenic selection model’. The complexity of cancers and heterogeneity of cancer patients set great barriers for identifying the ‘additive oncogene’. Here we introduce the high-throughput screening methods for identifying the state of oncogene addiction, including genomics, high-throughput proteomics, gene knockout system, and the emerging RNA interference. The ‘oncogene addiction’ theory can well explain the mechanism of target therapy and enforce the evidence for development of molecular target agents. ‘Oncogene addiction’ theory has been viewed as of great potential for cancer target therapy, although it faces some challenges and needs further research.
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Project Supported:
Project supported by the National High Technology Research and Development (863 Progam) Program of China (No. 2008AA02Z135)
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