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Advances of beast cancer metastasis related genes
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Abstract:
Abstract Breast cancer metastasis is a complicated process driven by multiple genes and follows multiple steps. The regulation of metastasis-associated genes is the molecular basis for metastasis. Metastasis-associated genes can promote or suppress the metastasis potential of tumor cells without affecting their growth and proliferation. Generally, metastasis-associated genes fall into two categories: metastasis-promoter genes and metastasis-suppressor genes, including oncogenes, tumor suppressor genes, signaling molecule genes, adhesion molecule genes, cytokine genes, matrix metalloproteinase genes, etc. The elucidation of the underlying mechanisms of breast cancer metastasis-associated genes and the related downstream signaling pathways can facilitate the molecular diagnosis and individualized therapy of patients with metastasic breast cancers.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No.30772504)
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