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Relationship of glucose transporter 1 and malignant tumor: an advance
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Abstract:
Abstract Tumor cells make compensation for ischemia and hypoxia through glucose transport, enhancement of glycolysis, and formation of tumor neoangiogenesis system. And glucose uptake is an important way to increase energy intake. Glucose transporter 1 (GLUT-1) is an important carrier of glucose transmembrane transport for tissue cells, and it is lowly expressed in mammalian embryos and mature tissues, but highly expressed in malignant tumor cells in a hypoxia and ischemia microenvironment. Expression of GLUT-1 is associated with tumor progression and prognosis. The regulation of GLUT-1 can be divided into acute and chronic pathways in tumor cells in an in vitro culture system. Chronic pathway concerning hypoxia-inducible factor-1 mRNA and protein syntheses is the main regulation pathway. Detection GLUT-1 expression in tumor tissues by immunohistochemistry and RT-PCR assay may provide a new way for tumor diagnosis. Blocking the fundamental energy source of tumor by GLUT-1-targeted therapy may provide a new strategy for cancer treatment.
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