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Transcription factors regulating expression of vascular endothelial growth factor and their relationship with tumor
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Abstract:
Tumor angiogenesis plays an important role in tumor development and progression, and it is a complex process regulated by many factors. Vascular endothelial growth factor (VEGF) plays a key role in the regulation of tumor angiogenesis, and it is regulated by cell genetic characteristics and many factors in tumor microenvironment at transcriptional, translation and post-translation levels, of which the regulation via transcription factor is the most important one. In this paper, we review the five most important transcription factors（Sp1，HIF-1，AP-1，Stat3 and NF-κB）and their relationship with expression of VEGF and tumors. In fact, downstream targets of these transcription factors, in addition to VEGF, also include many other angiogenesis promoting factors such as platelet-derived growth factor (PDGF) and fibroblast growth factors (FGF). Therefore, biotherapy strategy targeting these transcription factors may provide effective approaches for tumor anti-angiogenesis therapy.
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Project supported by the National Natural Science Foundation of China (No. 30901676)
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