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Myeloid-derived suppressor cells highly expressing CD14+DRlow/- in peripheral blood and tumor tissues of stomach carcinoma
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Abstract:
Objective:To investigate the expression of CD14+DRlow/- myeloid-derived suppressor cells (MDSCs) in peripheral blood and tumor tissues of gastric carcinoma (GC) patients and its relationship with clinicopathological of GC. Methods: Forty-three stomach carcinoma patients (9 stageⅠ, 13 stageⅡ, 14 stageⅢ, 7stageⅣ) were selected from Third Affiliated Hospital of Anhui Medical University (Mar. 2009 to Oct. 2010), and 26 healthy volunteers were used as control. CD14+DRlow/-MDSCs expression in peripheral blood and gastric carcinoma tissues was detected by flow cytometry, and its relationship with clinicopathological of GC was analyzed. Results: CD14+DRlow/-MDSCs expression in GC tissues was significantly higher than those in peripheral blood of GC patients and healthy controls (\[2.87±1.93\]% vs \[237±1.7\]%, \[0.89±0.47\]%, P<0.05 and P<0.01), and CD14+DRlow/-MDSCs expression in peripheral blood of GC patients was also higher than that in healthy controls (P<0.01). CD14+DRlow/-MDSCs expression in GC tissues was positively correlated with their malignancy stage and significantly increased in advanced GC (stage Ⅰ∶Ⅱ∶Ⅲ∶Ⅳ=(1.15±0.78)%∶(1.71±0.92)%∶(2.25±1.24)%∶(4.85±2.37)%, P<0.05). Meanwhile, CD14+DRlow/-MDSCs expression in tumor infiltration tissues was significantly higher than that in tumor un-infiltration tissues (\[3.90±167)% vs \[2.62±1.53\]%, P<0.05). Conclusion: CD14+DRlow/-MDSCs are highly expressed in peripheral blood and GC tissues, and relates to the development and progression of GC.
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Project Supported:
Project supported by the National “the Eleventh Five-Year” Major Science and Technology Program of China (No. 2009ZX10004-309)
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