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Expression of miR-29 in gastric cancer and its clinical significance
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Abstract:
Objective:To explore the expression of miR-29 in gastric cancer and its relationship with clinic pathological features and prognosis of gastric cancer. Methods: Totally 113 gastric cancer samples were obtained from patients who received operation during 2005 to 2010 in the No. 324 Hospital of PLA. The expression of miR-29 in gastric cancer and paracancerous tissues was detected by real-time PCR, and its relationship with clinic pathological features of gastric cancer was analyzed. Results: The expression of miR-29 in gastric cancer tissues was significantly lower than that in paracancerous tissues (2.62±1.17 vs 3.14±1.70, P=0.006). The rate of low miR-29 expression in patients with lymph node metastases was significantly higher than that without lymph node metastases (58.9% vs 32.5%, P=0.007). The median survival rate in low miR-29 expression cases was significantly lower than that in high miR-29 expression cases (33.0 vs 44.0 month, P=0.013). Conclusion: miR-29 is lowly expressed in gastric cancer tissues, and it might be used for prediction of prognosis and as for targeted treatment of gastric cancer.
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Project Supported:
Project supported by the Natural Science Foundation of Chongqing (No.2008BB5274, No.2009BB5314, No.2010BB5158)
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