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Expression of enolaseα and tumor M2 pyrurate kinase in gastric cancer and their clinical significances
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Abstract:
Objective:To investigate the expression, correlation and clinicopathological significance of enolaseα (ENO1) and tumor M2 pyruvate kinase (M2PK) in gastric cancer. Methods: Seventyeight paraffinembedded specimens of gastric tissues (55 gastric cancer and 23 gastric ulcer tissues) from the First Hospital of Lanzhou Universtiy (Jun. 2009 to Oct. 2010) were included in the present study. Expression of ENO1 and M2PK in gastric cancer and gastric ulcer tissues were detected by SP immunohistochemistry. Correlation between ENO1 expression and M2PK expression, and its implication in the clinicophathologic features of gastric cancer were analyzed. Results: The positive expression rate of ENO1 in gastric cancer tissues was significantly higher than in gastric ulcer tissues (67.3% vs 30.4%, P<0.01), and positively related to differentiation grade, depth of invasion, lymph node metastasis and TNM staging (all P<0.05). The positive expression rate of M2PK in gastric cancer tissues was significantly higher than in gastric ulcer (78.2% vs 391%, P<0.01), and positively related to differentiation grade (P<0.05), depth of invasion (all P<0.05). Expression of ENO1 was positively correlated to that of M2PK (r=0.5729, P<0.05). Conclusion: The upregulated expression of ENO1 and M2PK may participate in the oncogenesis and progression of gastric cancer. Combined detection of ENO1 and M2PK in gastric cancer tissues may be helpful in evaluating the prognosis of gastric cancer.
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Project supported by the Basic Scientific Research Foundation of Central University of China (lzujbky2010143)
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