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Expressions of coinhibitory molecules B7-H1 and B7-H4 in colorectal carcinoma and their clinical significances
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Abstract:
Objective:To examine the expression of coinhibitory molecules B7H1, B7H4 and infiltration of T cell subsets in colorectal carcinoma tissues, and to explore their clinical significances. Methods: Fifty tumor tissue specimens and 5 paracancerous tissues of 50 colorectal carcinoma (CRC) patients (from Jan. 2003 to Dec. 2003) in Fourth Affiliated Hospital of Soochow University were collected in the study. Immunohistochemistry staining was used for the detection of B7H1, B7H4 expression and T cell subset infiltration in CRC tissues, correlation between B7H1, B7H4 expression and clinical parameters of CRC patients was further analyzed. Results: B7H1 and B7H4 expression was found strong in CRC tissues but negative in paracancerous tissues (P<0.05). B7H1 expression in colon cancer tissues was significantly higher than that in rectal cancer (P<0.05), B7H4 expression was positively correlated to the Duke’s stage (P<005). B7H1 but not B7H4 expression in CRC tissues was negatively correlated to the infiltration of CD3+T cell (P<0.05). B7H1 expression was reversely related to the patients’ prognosis (P<0.05), and patients with high levels of both B7H1 and B7H4 showed a lower overall survival rate than other patients (P<0.05). Conclusion: Coinhibitory molecules B7H1 and B7H4 were highly expressed in human CRC tissues, and correlated to patients’ overall survival, and the joint detection of these molecules may have clinical value for diagnosis and prognosis of colorectal carcinoma.
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Project supported by the Innovative Research Fundation for Postgraduates in Medical College of Soochow University
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