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Expression and clinical significance of Foxp3 in breast carcinoma tissues
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Abstract:
Objective:To investigate the infiltration of Foxp3+ cells and expression of Foxp3 protein in breast carcinoma tissues and their clinical significance. Methods: One hundred and sixty breast carcinoma and 22 paracancerous tissues (who had been diagnosed in Shanghai Huangpu Center Hospital from Jan. 2005 to Dec. 2005) were included in present study. The infiltration of Foxp3+ cells and expression of Foxp3 protein in breast carcinoma and paracancerous tissues were detected by immunohistochemistry, and their relationships to clinicopathologic features and expression of ER,PR,P53,Bcl2,HER2 in breast carcinoma were analyzed. Results: Both positive rate of Foxp3+ cell infiltration in mesenchyma tissues and Foxp3 protein in parenchyma tissues were significantly higher than those in normal paracancerous tissues (P<0.05), but there was no correlation between the Foxp3+ cell infiltration and Foxp3 protein expression in breast carcinoma tissues (P>0.05). Foxp3+ cell infiltration in mesenchyma tissues was positively correlated to lymph node metastasis, histological grade and P53 overexpression (P<0.05); Foxp3 protein expression in parenchyma tissues was positively correlated to lymph node metastasis, histological grade, pTNM stage and P53 overexpression (P<005), but not to overexpression of ER, PR, HER2 and Bcl2 (P>0.05). Univariate survival analysis indicated that Foxp3 expression in breast carcinoma was associated with 5year overall survival rate, while multivariate analysis indicated that Foxp3 expression was not an independent prognostic factor for 5year overall survival rate in breast carcinoma (P>005). Conclusion: Foxp3 protein is overexpressed in breast carcinoma tissues, which might be a potential biomarker but not an independent prognostic factor in breast carcinoma.
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