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Detection and clinical significance of CD4+CD25+CD127low/- regulatory T cell in peripheral blood of papillary thyroid carcinoma patients
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Abstract:
Objective:To evaluate the propotion of CD4+CD25+CD127low/- regulatory T cells in peripheral blood of papillary thyroid carcinoma (PTC) patients and its clinical significance. Methods: Forty patients with PTC and 30 patients with thyroid adenoma were included in this study. They were all treated in Renji Hospital, Medical School of Shanghai Jiaotong University between August 2010 to February 2011. The proportion of CD4+CD25+CD127low/-Treg in peripheral blood of PTC and thyroid adenoma patients was evaluated by flow cytometry, and their relationship to clinicopathological features of PTC was studied. Results: Compared to thyroid adenoma patients, the proportion of CD4+CD25+CD127low/-Treg in peripheral blood of PTC patients was significantly increased (\[7.836±1.668\]% vs \[5.365±1.156\]%, P<005). The proportion of CD4+CD25+CD127low/-Treg was related to clinical tumor stage and cervical lymph node metastasis of PTC patients (all P<0.05), but not related to age, gender, and tumor size (P>0.05). Conclusion: The proportion of CD4+CD25+CD127low/-Treg in peripheral blood of PTC patients was significantly increased, and related to clinical tumor stage and cervical lymph node metastasis of PTC patients.
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