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Archive > Volume 20 Issue 2 > 2013,20(2):129-137. DOI:10.3872/j.issn.1007-385X.2013.02.001 Prev Next
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CIK cell therapy for cancer: Current status of international clinical trials and future prospects
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Abstract:
In recent years, the clinical trials on using cytokine induced killer (CIK) cells for solid tumor therapy have been launched worldwide. CIK cell immunotherapy has showed great advantages in clinical treatment compared with other adoptive immunity therapy, which is therefore more and more widely used in adoptive immunotherapy of tumors. CIK cells can be used alone or in combination with surgery, radiotherapy and chemotherapy for comprehensive treatment. In this article, we keep a track of research progress both home and abroad, briefly introduce the source, phenotype, activation and amplification of the CIK cells, and summarize their anti-tumor mechanisms, new techniques and methods, and current status of international clinical trials from several aspects. Some open questions about clinical treatment, standard management, quality monitoring, therapeutic evaluation and future directions are also explored.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 39270765), and the Natural Science Foundation of Heilongjiang Province (No. D201171)
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