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Archive > Volume 20 Issue 2 > 2013,20(2):225-229. DOI:10.3872/j.issn.1007-385X.2013.02.017 Prev Next
Clinical Research
Expression and clinical significance of fibroblast activation protein in non-small cell lung cancer
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Abstract:
Objective: To investigate the expression of fibroblast activation protein (FAP) mRNA in non-small cell lung cancer (NSCLC) tissue, and to evaluate its relationship with clinical characteristic and prognosis of NSCLC. Methods: Two hundred and forty-seven tumor specimens with NSCLC and forty-eight cases of corresponding adjacent tumor tissues selected from the Department of Biotherapy, Tumor Hospital Affiliated to Tianjing Medical University from June 2004 to December 2006. All cases were followed up until December 1, 2011. The FAP mRNA was detected by real-time PCR in NSCLC and normal tissues. Mann-Whitney-Wilcoxon U-Test was used to evaluate the association between clinicopathological parameters and FAP mRNA expression. Survival curves were plotted using Kaplan-Meier method, and survival difference was compared by the Log-rank, with Cox regression model to evaluate the independent prognostic factors. Results: FAP was over-expressed in NSCLC tissues. FAP mRNA expression level in NSCLC tissues were positively related to the Karnofsky Performance Score (KPS) (P<0.05), but not to the primary tumor location, size of tumor, lymph node metastasis, clinical stage and pathologic type of tumor (P>0.05). The median overall survival (OS) between patients with high FAP expression and low FAP expression showed no statistical significance (43 vs 39 months, P>0.05). Further histology hierarchical analysis showed that FAP mRNA expression in lung adenocarcinoma cancer patients was found to correlate inversely with clinical stages (P=0.031), and correlate positively with KPS (P=0.041). Lung adenocarcinoma lung cancer patients with high FAP expression had longer OS than did patients with low FAP expression (42 vs 26 months, P<0.05). Multivariate analyses showed that FAP expression was an independent prognostic predictor of lung adenocarcinoma cancer patients. Conclusion: FAP is over-expressed in NSCLC tissues. FAP is found to correlate inversely with clinical stage of lung adenocarcinoma cancer, and the expression of FAP is closely related to prognosis of lung adenocarcinoma cancer patients.
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Project Supported:
Project supported by the National Natural Science Foundation of China（No. 30901754）, and the National Key Basic Research and Development Project (973 Project) of China（No. 2012CB9333004）
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