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Archive > Volume 20 Issue 2 > 2013,20(2):237-241. DOI:10.3872/j.issn.1007-385X.2013.02.019 Prev Next
Clinical Research
XIAP and caspase-3 protein expressions in the evolution of colorectal adenocarcinoma
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Abstract:
Objective: To explore the clinical significance of the expressions of XIAP（X-linked inhibitor of apoptosis protein) and caspase-3 in colorectal adenocarcinoma and adenoma. Methods: Sixty-seven cases with colorectal adenocarcinoma, 30 cases of colorectal adenoma cases selected from the Department of Pathology, First Affiliated Hospital of Liaoning Medical College from 2010 to 2012 with surgical resection, and 30 cases of corresponding adjacent mucosa (the distance from the edge of the cancerous tissue 5 cm) were used as a control. Immunohistochemistry was used to detect the expressions of XIAP and caspase-3 proteins in colorectal adenocarcinoma and adenoma tissues; Western blotting was used to detect the expression of XIAP in the colorectal adenocarcinoma and adenoma tissues; The relationship between the expression of XIAP and the clinical pathology parameters of colorectal adenocarcinoma was analyzed. Results: The positive rate of XIAP expression in the colorectal adenoma group (71.6%) was higher than that in colorectal adenocarcinoma (46.7%), and its expression rate was increasing with the decrease of the tissue differentiation degree (χ2=16.132, P<0.05); the positive rate of caspase-3 expression in the colorectal adenocarcinoma tissues (18.0%) was lower than that in the colorectal adenoma group (43.3%), and its expression rate was decreased with the decrease of the pathological differentiation degree (P<0.05). The expression of XIAP protein was in a negative correlation with that of caspase-3 (r=-0.396, P<0.05). Conclusion: The XIAP protein might play a significant role in promoting the progress from colorectal adenoma to colorectal adenocarcinoma by inhibiting caspase-3.
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