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Archive > Volume 20 Issue 6 > 2013,20(6):631-636. DOI:10.3872/j.issn.1007-385X.2013.06.001 Prev Next
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Role of serine/arginine-rich splicing factor 1 in the development and progression of cancer
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Abstract:
Alternative splicing of pre-mRNA is an important mechanism of the proteomic diversity, and is closely related to the cancer development. Serine/arginine-rich splicing factor 1 (SRSF1), a typical member of alternative splicing family, is involved in diverse events including alternative splicing and processing, intracellur location and transportation of precursor mRNA. SRSF1 has been identified as an oncoprotein and is up-regualted in many cancers, including those of the lung, breast, as well as in leukemia. SRSF1 contributes to tumorigenesis and development by interacting with cancer-related genes, regulating cell cycle and apoptosis and other cell processes. Additionally, SRSF1 plays an oncogenic role through regulating the splicing of genes involved in several signaling pathways including PI3K-Akt-mTOR, Ras-MNK-MAPK and Wnt-β-catenin. For splicing disorders, the current treatment is to correct the missplicing of genes with antisense oligonucleotides, which has been widely applied in some solid tumors such as lung cancer and breast cancer. On this basis, further exploration in site selection and mechanism of alternative splcing will elucidate tumorigenesis and improve the diagnosis and treatment of cancer.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81070454)，and the High-level Training Project of Medical Technical Personnel in Beijing Health System (No. 2011-2-11)
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