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Phosphoinositide-3 catalytic subunit delta in gastric cancer: possible correlations with clinicopathologic characteristics and prognosis
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Abstract:
Objective : To analyze the correlation between the expression of phosphoinositide-3 kinase catalytic subunit delta (PIK3CD) and the clinicopathologic characteristics in gastric cancer tissues. Methods: A total of 86 paired tumorous and normal gastric tissue specimens were collected from gastric cancer patients who underwent surgical resection in the Department of Gastrointestinal Surgery, Liaoning Medical University-Affiliated First Hospital in Jinzhou between May 2005 and December 2007. The expression of PIK3CD at the protein level in these specimens was assessed by immunohistochemistry. The possible correlation between PIK3CD expression and the patients'clinicopathological characteristics and prognosis was analyzed by χ2 and Spearman correlation test. The influence of PIK3CD on 5-year survival and survival length was analyzed by Kaplan-Meier test. Results: The immunoreactive PIK3CD protein signal in the tumor proper was significantly stronger in the tumor proper than in the matched adjacent tissue (P=0.006). The intensity of PIK3CD protein signal was positively correlated with infiltration (P=0.005), but not with sex, age, differention, clinical stage, lympha nodes metastasis and distance metastasis (P>0.05). The 5-year survival rate was 18.9% and 60.6% in patients with high and low levels of PIK3CD respectively (P<0.05). The median survival length was 31.0 (95%CI: 23.9-38.1) months in patients with high levels of PIK3CD and 60.6 (95%CI: 53.8-67.4) months in patients with low levels of PIK3CD (χ2=19.791, P=0000). Elevated PIK3CD expression was an independent negative prognostic factor of gastric cancer (P= 0.000). Conclusion: PIK3CD may function as a pro-oncogeneand an independent prognostic factor in patients with gastric cancer.
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Project Supported:
Project supported by the the Public Welfare Scientific Research Foundation of Liaoning Province （No.2014001014）
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