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Influence of Helicobacter pylori infection on autologous DC-CIK maintenance therapy in the advanced gastric cancer patients
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Abstract:
Objective: To evaluate the effect of Helicobacter pylori (Hp) infection on the outcome of maintenance therapy with autologous dendritic cells-cytokine induced killer (DC-CIK) cells in gastric cancer patients. Methods: Seventy-two patients with advanced gastric cancer, aged 29-90 years, who were admitted to the Department of Oncology of No. 174 Hospital of PLA between June, 2010 and June, 2012 were included in this study. Based on the gastroscopic findings, patients were divided into two groups: Hp-positive and Hp-negative. Both groups received two courses of autologous DC-CIK immunotherapy after surgery or radiotherapy and chemotherapy. At the end of treatment, DC differentiation and maturation, treatment efficacy and patients outcomes in the two groups were analyzed. Results: No significant difference was observed in the morphology and maturation status of DCs between two groups (P>0.05). Levels of CD83 and CD86 on the surface of DCs were significantly higher in the Hp-positive group than those in the Hp-negative group (P<0.01), but surface levels of HLA-DR in DCs had no significant difference between two groups (P>0.05). In the Hp-positive group, the quality of life KPS score and levels of T lymphocyte markers (CD3+, CD4+ and CD8+) were significantly increased (P<0.05) but levels of tumor markers CEA, CA199 and CA724 were significantly decreased (P<0.05) after treatment. In the Hp-negative group, levels of tumor markers and the T lymphocyte markers were significantly different before and after treatment (P<0.05), but the KPS score was not significantly improved (P>0.05). Hp-positive patients had better KPS score, higher levels of CEA and CA199, and more abundant CD3+ CD4+T cells than Hp-negative patients (P<0.05）. In contrast, the two groups did not significantly differ in tumor stability, CA724 expression, and the number of CD8+T cells (P>0.05）. At the end of 2-years follow-up, the median survival time was 12.64 months in the HP-positive group and 11.42 months in the HP-negative group (P<0.05）. Conclusion: Hp infection may help stabilize the tumor size, improve the quality of life, and prolong the survival time in patients with advanced gastric cancer undergoing maintenance therapy with DC-CIK cells.
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Project Supported:
Project supported by the Medical Science and Technology Innovation Subject of Nanjing Military Region (No.10MA068), and the Science and Technology Innovation Project of Xiamen City（No.3502z20134026，No.3502z20144034）
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