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Tumor gene therapy: Current status and future prospectives
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Abstract:
Gene therapy is one of the most revolutionary medical technologies developing with the mature of the techniques of recombinant DNA and gene cloning and it is a kind of biomedical treatment based on changing human genetic materials. After nearly thirty years development, gene therapy has expanded from single-gene genetic diseases treatment to the therapy of malignant tumor, infectious diseases, cardiovascular disease, autoimmune disease, metabolic disease and other major diseases and about 2/3 of the gene therapy clinical trials are directed to malignant tumor. This article will mainly focus on the development history of world gene therapy and the development status of tumor gene therapy in China with emphases on the reviews of gene expression vector, gene delivery system, gene therapy clinical trials, the research and development of gene therapy major products and the industrialization development of gene therapy and the recent key breakthroughs in the malignant tumor and genetic diseases gene therapy fields. Besides, this article reviews with emphasis on the development opportunities and challenges of tumor gene therapy in the future from five aspects including gene delivery in vivo, safety of gene therapy, new technology in tumor gene therapy, tumor gene therapy combined with other therapeutic methods and gene detection technology united with gene therapy. We have reasons to believe that along with the continuous breakthroughs of key technologies of gene therapy, the next few years will be an important period of tumor gene therapeutic products coming to the market, which provides new choices for the clinical trials of malignant tumor.
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Project Supported:
Project supported by the National Key Basic Research Programs of China (No.2012CB917104), the National Programs for High Technology Research and Development of China(863 Program) (No.2012AA020802), and the Trans-Century Training Program Foundation for Talents from the Ministry of Education of China (No.NCET-11-0342 )
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