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The relationship of DNA methylation with multidrug resistance and prognosis in ovarian cancer
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Abstract:
Ovarian cancer is a malignant tumour that poses a serious threat to women's health. In most cases of ovarian cancer, drug resistance develops in the course of post-surgery chemotherapy. It has been well documented that DNA methylation is one of the important regulatory mechanisms underlying the development of multidrug resistance in ovarian cancer patients. However, the relationship between DNA methylation and drug resistance and clinical prognosis has yet to further understood. Through an electronic search of the PubMed database, we have identified 26 methylated genes that have been reported to be associated with the regulation of ovarian cancer drug resistance. Among these genes, at least half respond to ovarian cancer drug resistance by directly or indirectly regulating signaling pathways involved in cell apoptosis. Moreover, we have performed an integrated analysis of the relationship between these 26 methylated genes and the behaviour and prognosis of malignant ovarian cancer and have found that DNA methylation is primarily associated with poor prognosis. Herein in this review paper, we attempt to present the general information on the 26 identified methylated genes related to drug resistance, outline the putative molecular mechanisms through which DNA methylation affect drug resistance and discuss the possible strategies for reverse how the DNA methylation-induced drug resistance to improve prognosis in malignant ovarian cancer.
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Project Supported:
Project supported by the Specialized Research Funddation for the Doctoral Program of Higher Education of China（No. 20124503110003）， the Guangxi Scientific Research and Technology Development Program（No. 14124004），and the Guangxi Natural Science Foundation（No. 2014 jjAA40673）
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