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The relationship of XRCC1 Arg 399GLn（rs25487）and Arg280His（rs25489） polymorphisms with the family genetic susceptibility to hepatocellular carcinoma of Zhuang population in Fusui county of Guangxi
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Abstract:
Objective: To investigate the relationship between the Arg280His and Arg399Gln single nucleotide polymorphisms (SNPs) in the DNA repair gene XRCC1 and susceptibility to hepatocellular carcinoma（HCC）in members of liver cancer family of Zhuang population in Fusui county of Guangxi． Methods: Seventy-nine members of the 20 liver cancer families and 40 volunteers from 10 normal family groups were enrolled in this study. Genotypes of XRCC1 Arg399Gln（rs25487）and Arg280His（rs25489) SNPs were determined by Time of Flight Mass Spectrometer (MS-TOF) analysis. The potential association between the XRCC1 rg399Gln（rs25487）and Arg280His（rs25489）polymorphisms and HCC risk was evaluated by non-conditional logistic regression analysis. Results: In the normal control families, the risk of HCC for members with AG and AA genotypes in rs25487 was 9 (95% CI=0.828- 97.780， P =0.071 ) and 5.143 (95% CI=0.445-59.45， P =0.190) times higher than that of members with GG genotype. In the liver cancer families, the risk of HCC for members with AG and AA genotypes in this SNP was 4 (95% CI=0.689-23.230， P =0.122) and 2.857 (95% CI= 0.464～17.583， P =0.257）times higher than that of members with GG genotype. For SNP rs25489, the risk of HCC for members of the normal control families with GA genotype was 2.4 (95% CI= 0.530-10.877， P =0.256 ) times higher than that of members with GG genotype. In the liver cancer families, the risk of HCC for members with GA genotype was 1.02 （95% CI=0.286-3.650， P =0.973） times higher than that of members with GG. Conclusion: There is no statistic significant correlation between Arg399Gln（rs25487）and Arg280his（rs25489）polymorphisms in XRCC1 gene and susceptibility to HCC in family with liver cancer in Fusui county of Guangxi province.
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Project Supported:
Project supported by the National Natural Secience Foundation of China(No.81260320), and the 2013 Innovation project of Guangxi Graduate Education （No. YCBZ2013012）
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