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The influence of the receptor expression alteration in locally recurred tumor on the prognosis of breast cancer patients
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Abstract:
Objective: To assess the influence of the receptor expression changes in locally recurred tumors on the prognosis of breast cancer patients. Methods: The primary and recurrent tumor sections from 56 patients admitted to our department from January 2008 to December 2013 for both primary and recurrent breast cancers were investigated. The expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2(Her-2) was examined by immunohistochemistry. The association between changes of the receptors expression and overall survival (OS) of patients was then analyzed. Results:（1）The positive rates of the ER, PR, and Her-2 in the primary tumor and recurrent tumor sections were 64.29% and 55.36%, 53.57% and 39.29%, and 37.50% and 35.71 respectively. (2) The rates of altered expression between the primary and recurrent tumors for ER, PR, and Her-2 are 33.93% (16/56) 37.50% (21/56), and 8.93% (5/56). (3) Among 56 breast cancer patients, there were 22 death (39.29%) during the investigation period, the median survival time was 21.5 months, and the survival rates for 1 -5 years were 87.23%, 75.65%, 70.11%, 60.22%, 42.86%. Kaplian-Meier analysis revealed that alterations of ER and PR expression in primary and recurrent tumors affect OS of the patients. Patients whose ER and PR expression in primary and recurrent tumors changed from negative to positive have better prognosis than those who had ER and PR expression changed from positive to negative (P<0.05). There were not enough positive sections in this cohort to evaluate the effects Her-2 alterations. (4) Multivariable analysis indicated that age, tumor pathological type, stage, and metastasis, ER and PR expression are all independent prognostic factors for the OS of breast cancer.patients. Conclusion: The alteration of ER and PR expression in primary and recurrent tumors of breast cancer patients affects their OS. Assessing these changes will benefit the treatment and prognosis evaluation.
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