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Meta-analysis of chemotherapy combined with cytokine-induced killer cells in the treatment of gastric cancer
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Abstract:
Objective: To evaluate the effectiveness of chemotherapy combined with adoptive transfer of cytokine-Induced killer cells (CIK) in the treatment of gastric cancer. Methods: We searched for randomized controlled clinical trials of gastric cancer treatment in PubMed, EMBASE, Web of Science, Chorane, CNKI, and VIP database from January 1990 to March 2014. Meta analysis was performed with the Revman 5.2 software. Results: We found 5 studies that enrolled 306 patients met the criteria. Analysis of the data indicated that, compared with chemotherapy alone, chemotherapy combined with adoptive transfer of CIK in the treatment of gastric cancer improved the short and long term responses. The detail short term remission rate and long term (1, 2, and 3 years) survival rates are as follow: short term （RR=2.14，95% CI: 1.20~ 3.79， P =0.01， I 2=0%）, 1-year (RR=1.13，95% CI: 1.03~1.24， P =0.09， I 2=50%), 2-year（RR=1.22，95% CI: 1.11~1.44， P =0.46， I 2=0%), 3-year（RR=1.34，95% CI: 1.10~1.63， P =0.5， I 2=0%）. The combined therapy also significant prolonged the progress-free survival of patients (RR= 2.65，95% CI：229~3.01\]， P <0.001， I 2=98%). Conclusion: Chemotherapy combined with adoptive transfer of CIK can improve the overall response and progress-free survival of gastric cancer patients.
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Project Supported:
Project supported by the Key Medical Scientific Research Program of “Twelfth Five-year Plan” of the Army（No. BWS12J051）
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