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Current situation and development trend of CAR-NK anti-tumor research
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Abstract:
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective immunotherapy for cancer. With the rise of CAR-T technology, potential of CAR modification in NK cells has been also concerned. The research and application of CAR-NK not only inherited some ideas of classic CAR-T, but also achieved a lot of innovations and developments based on biological characteristics of NK cells. Peripheral blood NK cells, NK cells lines and NK cells derived from stem cells exert various biological characteristics and had been widely used in the researches and developments of CAR-NK. A lot of remarkable results have been obtained in the preclinical tests and animal experiments of CAR-NK targeting to hematologic and solid tumors. CAR-NK could make a novel breakthrough in treatment of solid tumor and simplification of imunotherapy, although there is no clinical data supporting the efficacy of CAR-NK till now and some bottleneck problems still need to be overcome.
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Project Supported:
Supported by the National Key Science and Technlogy Program of China （No. 2012ZX10002006-001-004,No.2012ZX10002014-002）, the National High-tech R & D Program of China (863 Program) （No.2012AA020902）, and the General Program of National Natural Science Foundation of China （No. 31570873）
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