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Archive > Volume 23 Issue 1 > 2016,23(1):102-105. DOI:10.3872/j.issn.1007-385X.2016.01.017 Prev Next
Clinical Research
Expression and clinical significance of connective tissue growth factor in ovarian carcinoma
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Abstract:
Objective:To investigate the expression and clinical significance of connective tissue growth factor (CTGF) in ovarian cancer. Methods: The expression levels of CTGF in 20 cases of normal ovarian tissues，30 cases of benign ovarian tumor tissues and 105 cases of ovarian cancer tissues were examined by RT-PCR and immunohistochemical staining, and the correlation between CTGF expression and clinicopathological significance of ovarian cancer was analyzed. Results: The positive rate of CTGF expression in normal ovarian tissues, benign ovarian tumor tissues and ovarian cancer tissues were 95.00%（19/20），93.33%(28/30) and 53.33%（56/105）respectively; the positive rate of CTGF in ovarian cancer tissues was significantly lower than that of normal ovarian tissues（χ2=12.15, P=0.00) and benign ovarian tumor tissues（χ2=15.88, P=0.00）; there was no significant difference in the positive rate between normal ovarian tissues and benign ovarian tumor tissues（χ2=15.88, P=0.00）. The CTGF mRNA expression in ovarian cancer tissue was lower than that in normal ovarian tissue and benign ovarian tumor tissue showed by RT-PCR ( F=3.39，P=0.039）. Data was processed by χ2 analysis, and the results showed that the expression of CTGF was correlated with clinical stages, lymph node metastasis（P<005）, but not correlated with age, pathologic type，pathologic grade and positive rate of ascites tumor cells (P>0.05）. Conclusion：CTGF was low expressed in overian cancer tissues and correlate with the occurrence and progression of ovarian cancer.
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Project Supported:
Project supported by the Science and Technology Support Plan of Qingdao Public Domain（No.13-1-3-62-nsh）
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