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Archive > Volume 23 Issue 3 > 2016,23(3):378-381. DOI:10.3872/j.issn.1007-385X.2016.03.014 Prev Next
Clinical Research
Expression of Beclin1 in non-small cell lung cancer and its relationship with EGFR mutation
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Abstract:
Objective:To observe the expression of Beclin1 in the tissues of non-small cell lung cancer (NSCLC) and to investigate its correlation with EGFR mutation. Methods: Immunohistochemistry and DNA sequencing were used to detect the expression of Beclin1 and EGFR mutation in 42 patients with NSCLC, respectively. The clinical significance and their correlations were analyzed. Results: he expression levels of Beclin1 were significantly higher in NSCLC tissues than that in the para-carcinoma normal tissues（71.4% vs 30.9%, P<0.01). The expression of Beclin1 in NSCLC was associated with smoking history and histological type (P=0.005, P=0.025). There were 14 cases with EGFR mutation, among which 11 cases expressed high level of Beclin1 and 2 cases expressed low level of Beclin1, with a mutation rate of 57.9% (11/19) vs 16.7% (2/12). EGFR mutation and the expression of Beclin1 had a significant correlation (r=0416, P=0009).Conclusion: EGFR mutation in NSCLC patients was positively correlated with Beclin1 expression. Beclin1 could help to determine EGFR mutation in NSCLC patients at certain level, and could provide a meaningful evidence to determine EGFR mutation.
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Project Supported:
Project supported by Shanghai Science Committee (No.15411960400)
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