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Archive > Volume 23 Issue 4 > 2016,23(4):515-518. DOI:10.3872/j.issn.1007-385X.2016.04.010 Prev Next
Clinical Research
Natural killer cell treatment for advanced hepatocellular carcinoma patients: an observation of recent clinical curative effect
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Abstract:
Objective:To observe and evaluate the clinical efficacy and safety of natural killer cells (NK) on advanced hepatocellular carcinoma (HCC), as well as its influence on the activities of lymphocyte subsets and natural killer (NK) cells in peripheral blood of HCC patients. Methods: We collected peripheral blood (PB) from 30 patients with advanced hepatocellular carcinoma from September 2013 to September 2015 at No. 307 Hospital of PLA. The NK cells were generated through cultivation and induction in vitro, and were re-transfused into patients at the 14th and the 15th day. Two consecutive transfusions were regarded as one cycle, and there were totally two cycles. We detected the activities of lymphocyte subsets and NK cells in peripheral blood at pre-treatment and 2 weeks post-treatment for each cycle, respectively, and observed the activity changes of the lymphocyte subsets and NK cells before and after the treatment as well as its relationship to clinical efficacy. Results: Among the 30 HCC patients, there were 4 cases of PR, 19 cases of SD and 7 cases of PD after NK treatment; the objective response rate and disease control rate were 13.3% and 76.7 % respectively. The lymphocyte subsets didn't show obvious change, but the NK cell activity increased significantly after the treatment (\[5.06±4.46\]% vs \[6.68±3.83\] %, P<0.05). None of the 30 patients had adverse effects. Conclusion:The NK cell immunotherapy can improve the anti-tumor and immunity effect of body and slow-down the disease progression; it is a new and safe treatment approach for HCC patients.
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Project Supported:
Project supported by the Key Science and Technology Foundation of “12th Five-Year Plan” of China (No.2009zx09503)
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