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Archive > Volume 23 Issue 4 > 2016,23(4):531-536. DOI:10.3872/j.issn.1007-385X.2016.04.013 Prev Next
Clinical Research
Expressions of melanoma associated antigen-As in tissues of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma and its clinical significance
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Abstract:
Objective:To investigate the expressions of melanoma antigen (MAGE)-As in esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcioma (GCA), and to explore its correlation with clinical biological indicators and the prognosis in patients with ESCC and GCA. Methods: Cancerous (n=60) tissue samples and corresponding normal (n=60) adjacent tissues with normal morphology that 5 cm away from the lesions were collected from 60 patients with ESCC or GCA, who were surgically treated in Fourth Hospital of Hebei Medical University between September and November of 2010. In the meanwhile, testicular tissues (n=5) were collected from Men with prostate cancer as the positive control. Immunohistochemical staining was performed to assess the expressions of MAGE-As in carcinoma tissues and adjacent normal tissues. Results: The expression rates of MAGE-As protein in the tissues from ESCC and GCA were 6833% (41/60) and 58.33% (35/60) respectively, but it was not expressed in adjacent normal tissues. No correlation was found between MAGE-As protein expression and the age, gender, histological grade, clinical stage, tumor size, lymph node metastasis in patients with esophageal squamous cell carcinomas (P>0.05). MAGE-As protein expression was not correlated to the gender, age, clinical stage, tumor size, lymph node metastasis in patients with gastric cardia adenocarciomas (P>0.05), but positively related to the histological grade (P<0.05). Log-rank test showed that the survival time of ESCC patient (P=0.036) and GCA patients (P=0.045) with positive MAGE-As expression were significantly lower than those of the patients with negative expressions. Conclusion:MAGE-As proteins are the ESCC and GCA associated antigen. It may be regarded as a potential diagnostic and prognostic index in clinical settings.
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Project Supported:
Project supported by the Financial Supporting Program of Hebei Province(No.\[2012\]2056) , Science and Technology Supporting Program of Hebei Province (No.14277732D), and the Science and Technology Program of Hebei Province (No.152777184)
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