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Archive > Volume 23 Issue 5 > 2016,23(5):595-600. DOI:10.3872/j.issn.1007-385X.2016.05.002 Prev Next
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Exploration of using nanotechnologic detection for circulating tumor cell for diagnosis of early cancer
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Abstract:
Existence and circulation of circulating tumor cell (CTC) in peripheral blood is recognized as a primary reason for distant metastasis of tumor. Compared with the conventional imaging diagnosed methods, CTC detection as a non-invasive detection approach is operation simpler, safer and more accurate. Moreover, CTC technique also helps researchers to explore further the mechanisms of tumor metastasis, recurrence and chemotherapy resistance. Therefore, CTC as a sensitive biomarker has important clinical significance in tumor screening, early diagnosis, prognostic evaluation and monitoring of curative efficiency. “Tumor fisher” developed by CAS is a technology which captures the CTC in peripheral blood using polypeptide nano magnetic beads. At present, the CTC detective technique has been used for clinical research and trial in many advanced public hospitals of China. A lot of clinical data indicated that this technology might have great guide significance for early diagnosis, prognostic judge and monitoring of drug resistance. The article will explain progresses of the CTC research, development and application of the “tumor fisher” technique.
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Project Supported:
Project supported by the National High-tech R&D Program of China（No.2015AA02408），the National Natural Science Foundation of China（No. 31470049，No. 31270875），and the Municipal Science and Technology Plan of Beijing（No. 2014-2015）
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