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Archive > Volume 24 Issue 12 > 2017,24(12):1343-1349. DOI:10.3872/j.issn.1007-385X.2017.12.001 Prev Next
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Precise mechanisms by which TIM-3 regulates immune response
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Abstract:
Dynamic change and spatial characteristics of immune response is one of the fundamental theories of precision medical treatment. One certain immune regulator may have totally different functions under different temporal and spatial distribution. T cell immunoglobulin domain and mucin domain protein-3 (TIM-3) is a recently identified immune checkpoint inhibitor. Like PD-1 and CTLA-4, TIM-3 contributes to immune homeostasis. Recently, TIM-3 has attracted much attention as its dysregulated over-expression was approved to be associated with tumors and chronic viral infections.Strategies targeting immune checkpoints are now showing therapeutic prospect. However, the low efficiency rate, therapy resistance and even side effects still exist, which call for precise mechanisms investigation. Most of the research indicates the immune inhibitory effect of TIM-3; still, there are some reports on opposite conclusion. TIM-3 has multiple ligands,and the intra-cellular signaling mechanism is still unclear. In addition, the function and clinical significance of soluble TIM-3 protein in plasma remain unclear. If TIM-3 acquired multiple functions following the evolution of immune system,clarify the mechanisms by which TIM-3 regulates immune response will provided much important information for its further investigation.
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Project Supported:
Project supported by the National Key Basic Research Program (973 Program) of China（No.2013CB530506），the National Natural Science Foundation of China（No. 81471540），and the National Natural Science Foundation of Beijing City（No. 7141007）
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