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Archive > Volume 26 Issue 10 > 2019,26(10):1083-1088. DOI:10.3872/j.issn.1007-385X.2019.10.005 Prev Next
Basic Research
Preparation of indocyanine green loaded mesoporous silica nanoparticles and their killing effect on cervical carcinoma HeLa cells
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Abstract:
[Abstract] Objective: To construct indocyanine green-loaded silica nanoparticles (ICG@MSNs) and evaluate their killing effect on cervical cancer HeLa cells. Methods: Mesoporous silica nanoparticles (MSNs) were synthesized by template method, and indocyanine green (ICG) containing photothermal agent was loaded to prepare ICG@MSNs with photothermal effect, which were applied in the research of HeLa cells in vitro. Results: The particle of ICG@MSNs was uniform and in regular spherical shape with the size about 200 nm. ICG@MSNs was similar photothermal effect with pure ICG. Cell endocytosis experiments showed that ICG encapsulated in silica nanoparticles is more likely to be endocytosed by tumor cells, and then played a photothermal role in killing cervical cancer HeLa cells. On the other hand, cytotoxicity experiments showed that under the irradiation of 808 nm laser, ICG@MSNs significantly increased cytotoxicity, which could significantly kill cervical cancer HeLa cells. Conclusion: ICG@MSNs has good stability and biocompatibility,as well as good thermogenesis. It’s photothermal treatment effect on tumor is obvious, which has a good prospect for the treatment of cervical cancer.
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Project Supported:
Project supported by the Natural Science Youth Foundation of China (No.1701444)，and the Special Project of Clinical Medical Research of Chinese Medical Association (No.17020380707)
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