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Archive > Volume 27 Issue 3 > 2020,27(3):213-220. DOI:10.3872/j.issn.1007-385X.2020.03.001 Prev Next
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In situ vaccine: new ideas for tumor immunotherapy
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Abstract:
New strategies for cancer immunotherapy have developed rapidly in recent years. Regarding how to achieve the optimal anti-tumor immune effect,“passive”immunotherapy such as adoptive cell transfer therapy, genetically engineered T cells, etc. can be used to directly attack tumor cells while“active”immunotherapy such as cytokines, cancer vaccines, immune checkpoint inhibitors,etc. can be used to regulate and activate immune system. In situ vaccine, using intratumoral administration of immunomodulators,combines“active”and“passive”immunotherapies scientifically at the same time, forming a cycle composed of immune priming-immune activition-tumor cell death-antigen release resulting in immune priming-immune activition, ultimately maximizing the anti-tumor immune effect. This review describes the specific strategies, promising preclinical results and some clinical trials as well as advantages,challenges and perspectives of in situ vaccine.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No.81672367)
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