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Archive > Volume 27 Issue 9 > 2020,27(9):959-967. DOI:10.3872/j.issn.1007-385X.2020.09.001 Prev Next
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Current status and challenges of TCR-T therapy in solid tumor
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Abstract:
T cell receptors (TCR) are specifically expressed on T cell surface, which can recognize different tumor antigens to kill and scavenge cancerous cells. TCR-engineered T cells (TCR-T) therapy is to harbor TCR specific to tumor cells and modify the T cells with genetic engineering techniques to achieve the purpose of treating tumors after transfusion. Despite some achievements in TCR-T therapy,there are still some problems, such as treatment toxicity, limited T cell infiltration and antigen-specific deficiency and so on. So, the safety and effectiveness of TCR-T therapy need to be constantly optimized. Therefore，this paper summarizes the research status of TCR-T therapy for solid tumors in domestic and overseas, as well as the existing problems and countermeasures.
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Project Supported:
Project supported by the Joint Funds for the Innovation of Science and Technology in Fujian Province (No.2018Y9108)
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