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Single-cell transcriptome sequencing and tumor precision medicine
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Abstract:
Single-cell sequencing is a new technology for comprehensive analysis of genetic information at single cell level through high[1]throughput sequencing technology. Single-cell sequencing has become a powerful tool for in-depth research in modern biology. Single-cell sequencing technologies have enabled the research in biomedical field and clinical translation to achieve a high level of accuracy and sensitivity that traditional sequencing technology couldn’t achieve. At present, single-cell transcriptome sequencing (often referred to as “single-cell RNA sequencing”, scRNA-seq) has become the most widely used single-cell sequencing technology. In this paper, the development history, technical principles and methods of scRNA-seq are briefly introduced. In addition, the research achievements of scRNA-seq in the basic research fields of tumor heterogeneity, tumor metastasis, tumor immunity and tumor drug resistance, as well as its research progress on translational medicine and application in tumor precision medicine are systematically described, in hope to promote tumor precision medicine to a higher level through the development and application of single-cell sequencing technology.
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Project Supported:
Project supported by the Program for High Level Entrepreneur‐ ial and Innovative Talents Introduction (No.JSP-ORB2019-12-04)
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