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Archive > Volume 29 Issue 4 > 2022,29(4):267-275. DOI:10.3872/j.issn.1007-385X.2022.04.001 Prev Next
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Epigenetic regulation of polarization and functional reprogramming of tumor-associated macrophages：a novel strategy of cancer therapy
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Abstract:
Tumor-associated macrophages (TAMs), key players in tumor development, metastasis and drug resistance, contain two polarizable phenotypes: inflammatory, tumor-inhibitory M1 type and anti-inflammatory, tumor-promoting M2 type. Epigenetic regulation plays a distinct role in functional programming of TAMs in the tumor microenvironment. It determines the polarization and function of TAMs mainly through mediating transcriptional or post-transcriptional regulation of polarization-related signal pathways, cytokines, metabolic enzymes, key transcription factors, MHC and its regulators. Therefore, epigenetic regulation-based inhibition of M2 polarization and promotion of M1 polarization to induce functional reprogramming of TAMs has gradually developed into a novel strategy in the field of antitumor immunotherapy. Identification of more specific and pivotal mechanisms in epigenetic regulation of TAMs and development of new TAM-targeting epigenetic drug delivery system, combined with other antitumor therapies, might improve targeting specificity of epigenetic regulation of TAMs, reduce adverse effects and achieve better antitumor effects.
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Clc Number:
R730.51；R730.3
