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Archive > Volume 29 Issue 4 > 2022,29(4):276-283. DOI:10.3872/j.issn.1007-385X.2022.04.002 Prev Next
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The application strategies of glycan metabolic labeling in tumor targeted therapy
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Abstract:
The specific recognition and binding of tumor cells are crucial to targeted therapy. However, lacking effective targets is still the main challenge for targeted therapy. Glycan metabolic labeling provides a potential approach for tumor targeted therapy with advantages of in vivo labeling, high labeling efficiency, low toxicity and less interference. Through labeling tumor cells with hapten, antigen, chemotherapeutic drugs and cytotoxic drugs, labeling strategy based on glycan metabolism realizes the specific recognition of tumor cells or stimulates cellular and humoral immune responses in vivo. In addition, through labeling immune cells, this strategy also improves immune cells’specific recognition and binding of tumor cells. The strategy of glycan metabolic labeling provides broad application prospects in tumor targeted therapy.
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Clc Number:
R730.54；Q591.4
