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Archive > Volume 29 Issue 6 > 2022,29(6):567-570. DOI:10.3872/j.issn.1007-385X.2022.06.008 Prev Next
Clinical Research
Clinicopathological features of real-world multiple primary cancers and their diagnosis and treatment strategies
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Abstract:
Objective: To review the clinicopathological features of real-world multiple primary cancers (MPCs) and their traditional combine with biological treatment strategies, in order to improve the diagnosis and treatment of MPCs. Methods: The clinical data of tumor patients admitted to the Department of Oncology of Nanjing First Hospital and the General Surgery Department of Jiangsu Hospital of Traditional Chinese Medicine from January 2016 to December 2021 were retrospectively analyzed. All the patients were diagnosed as malignant tumors after pathological examination, and the incidence, pathological characteristics, clinical treatment and prognosis of MPCs were summarized and analyzed. Results: Among the 2 550 patients with malignancy, there were 24 patients with MPCs, with an overall incidence of 0.94% (24/2 550); specifically, the incidence of double cancer was 0.86% (22/2 550) and the incidence of triple cancer was 0.08% (2/2 550). There were 15 cases (62.5%, 15/24) having the second primary cancer within 3 years and 18 cases (75%, 18/24) within 5 years, with a maximum interval of 30 years. Digestive tumors are the most common ones in both the first and second primary cancers, followed by respiratory tumors. The 3- and 5- year survival rates after surgery, radiotherapy or chemotherapy was 58.3% (14/24) and 45.8% (11/24), respectively. Conclusion: By improving the understanding of the clinicopathological features and the traditional combined with biological treatment strategies of MPCs, we can achieve early diagnosis and treatment (avoid missed diagnosis) of MPCs to prolong the survival of patients and improve their quality of life.
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