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Archive > Volume 32 Issue 3 > 2025,32(3):233-238. DOI:10.3872/j.issn.1007-385X.2025.03.001 Prev Next
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Research progress on biomaterials-based integrated strategies for tumor prevention, treatment, and organ protection
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Abstract:
[Abstract] In the field of cancer treatment, traditional therapeutic means such as surgery, chemotherapy and radiotherapy have achieved certain results, but they are often associated with severe side effects, high recurrence rate and serious damage to normal tissues. In recent years, with the rapid development of biomaterials science, integrated biomaterials for tumor prevention, treatment, and organ protection have gradually become a research hotspot. According to dimensional structures, these biomaterials can be classified into small-molecule drugs, zero - dimensional, one - dimensional, two - dimensional, three - dimensional biomaterials, multi dimensional composites, and active biomaterials. Zero-dimensional biomaterials, such as Prussian blue nanozymes and gold nanoparticles, are enabled tumor suppression and tissue regeneration. One-dimensional materials, like nanotubes, facilitate drug loading and enhance wound healing. Two-dimensional biomaterials like laponite can be used to construct the nanocomposite system gelatin laponite-doxorubicin (GLD), which significantly enhances the killing ability against tumor cells. Three-dimensional biomaterials, such as hydrogels, are applicable for tumor therapy and tissue repair. Composites formed by zero - dimensional materials and two - or three - dimensional biomaterials can achieve long - term slow release of zero - dimensional biomaterials and simultaneously play the functions of tumor prevention and treatment and organ protection. When designing biomaterials, it is critical to holistically evaluate their strengths and limitations, leveraging nanotechnology and bioengineering strategies to achieve precise tumor targeting and organ preservation. By integrating anti-tumor drugs and tissue repair factors, these materials aim to achieve inhibition of tumor growth while promoting repair and regeneration of damaged tissues, providing new ideas and methods for tumor treatment.
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