Mobile website
Archive > Volume 32 Issue 6 > 2025,32(6):636-640. DOI:10.3872/j.issn.1007-385X.2025.06.010 Prev Next
Clinical Research
Expression of FLG in melanoma tissues and its correlation with clinicopathological features and prognosis
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
[Abstract] Objective: To explore the expression of filaggrin (FLG) in melanoma tissues and its correlation with clinicopathological features and prognosis in patients. Methods: A total of 70 melanoma patients treated at the People’ s Hospital Affiliated to Shandong First Medical University from June 2019 to August 2020 were selected as research subjects. Tumor tissues and adjacent tissues obtained during surgery were examined for FLG expression using immunohistochemistry. Based on FLG expression, patients were divided into a positive group and a negative group. The positive expression rates of FLG in tumor tissues, adjacent tissues and melanoma tissues with different pathological features were compared. The patients were followed up for 3 years, and based on prognosis, they were divided into a survival group (n = 43) and a death group (n = 27). The FLG positive expression rates were compared between the two groups. Kaplan-Meier survival curves were plotted, and survival times were compared. Results: The positive FLG expression rate in melanoma tissues was significantly lower than that in adjacent tissues (P < 0.05). The proportions of patients with tumor diameter > 1 cm, Breslow thickness > 2 mm, local ulcer, TNM stage Ⅲ-Ⅳ, lymph node metastasis, and tumor invasion in positive FLG expression group were significantly lower than those in negative group (P < 0.05 or P < 0.01). Among the 70 patients, 27 cases died and 43 survived, with a survival rate of 61.42%. The positive FLG expression rate was significantly lower in death group than that in survival group (P < 0.05). The survival time of FLG-positive patients was significantly longer than that of FLG-negative patients (P = 0.010). Multivariate Cox regression analysis revealed that Breslow thickness > 2 mm, TNM grade Ⅲ-Ⅳ, lymph node metastasis, and tumor invasion were risk factors for the prognosis of melanoma patients (P < 0.01 or P < 0.001), while positive FLG expression was a protective factor (P < 0.01 or P < 0.001). Conclusion: FLG expression is significantly decreased in melanoma tissues and is associated with pathological features such as Breslow thickness, tumor stage, invasion, lymph node metastasis, and prognosis.
Keywords:
Project Supported:
Clc Number:
