Mobile website
Editorial
The application of next-generation humanized immune system mouse models in cancer biotherapy: progress and challenges
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
[Abstract] While murine models remain the cornerstone of biomedical research and play important roles in the exploration of human disease mechanism and therapeutic strategies, inherent genetic and immunological discrepancies between species constitute a major barrier to the translational success of basic research. Humanized immune system mouse models have therefore emerged with great significance and broad translational potential. This review systematically outlines the evolution of humanized immune system mouse models and delineates the key technical development and optimizing strategies from first-generation models relying on cell or tissue transplantation to second-generation and more refined genetically engineered models, driven by the incorporation of human cytokine expression and CRISPR/Cas9 technology. Special attention is given to technical advancements of the new-generation model in optimizing myeloid and NK cell development and accurately recapitulating the human tumor immune microenvironment. Additionally, this article provides an in-depth analysis of the application and challenges of these humanized immune system mouse models in the evaluation of immune checkpoint inhibitors, bispecific antibodies, antibody-drug conjugates, immune cell therapies and other therapeutic modalities, as well as toxicity prediction such as cytokine release syndrome. Concluding with a perspective on the development of immune system humanized and personalized models in precision medicine and pre-clinical assessment, this review aims to offer insights into optimizing new drug development strategies and promoting translational success rates.
Keywords:
Project Supported:
Clc Number:
